Acute Schistosomiasis with A S. Mattheei x S. Haematobium Hybrid Species in a Cluster of 34 Travelers Infected in South Africa.
| dc.contributor.author | Cnops, L. | |
| dc.contributor.author | Huyse, T. | |
| dc.contributor.author | Maniewski , U. | |
| dc.contributor.author | Soentjens , P. | |
| dc.contributor.author | Bottieau , E. | |
| dc.contributor.author | Van Esbroeck, M. | |
| dc.contributor.author | Clerinx , J. | |
| dc.date | 2020 | |
| dc.date.accessioned | 2024-03-14T13:22:49Z | |
| dc.date.available | 2024-03-14T13:22:49Z | |
| dc.identifier.issn | 1058-4838 | |
| dc.identifier.uri | https://orfeo.belnet.be/handle/internal/12628 | |
| dc.description | BACKGROUND: Diagnosis of schistosomiasis remains elusive soon after infection. We evaluated several diagnostic methods in a cluster of travelers simultaneously exposed to freshwater in South Africa. METHODS: Eosinophil count, schistosome antibody tests, stool and urine microscopy, and serum Dra1 PCR assays were performed at week 4-5 (w4-5, early symptomatic phase), week 7-8 (w7-8, praziquantel treatment), and week 12-14 (w12-14, post-treatment). Sequencing was done on serum of 3 patients to identify the species. RESULTS: Of the 34 travelers (16 adults, 18 children), 32 developed symptoms 2 to 6 weeks after exposure. A raised eosinophil count (>750/µL) count was seen in 12/33 at w4-5, and in 22/34 at w7-8. Schistosoma antibodies were detected in 3/33 at w4-5, in 12/34 at w7-8 and w12-14. The Dra1 PCR was positive in 24/33 travelers at w4-5, in 31/34 at w7-8, in 25/34 at w12-14, and at least once in all. Ova were absent in all urine and fecal samples obtained. Sequencing identified S. mattheei nuclear and S. haematobium mitochondrial DNA, indicative of a hybrid species. CONCLUSION: The Dra-1 PCR confirmed diagnosis in all exposed travelers at a much earlier stage than conventional tests. The causative species is probably a S. mattheei x S. haematobium hybrid. | |
| dc.language | eng | |
| dc.title | Acute Schistosomiasis with A S. Mattheei x S. Haematobium Hybrid Species in a Cluster of 34 Travelers Infected in South Africa. | |
| dc.type | Article | |
| dc.subject.frascati | Clinical medicine | |
| dc.audience | Scientific | |
| dc.subject.free | Invertebrates | |
| dc.source.title | Clinical Infectious Diseases | |
| Orfeo.peerreviewed | Yes | |
| dc.identifier.doi | https://doi.org/10.1093/cid/ciaa312 | |
| dc.identifier.rmca | 5952 |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||