The embryonic cell lineage of the nematode Rhabditophanes sp.
| dc.contributor.author | Houthoofd, W. | |
| dc.contributor.author | Willems, M. | |
| dc.contributor.author | Jacobsen, K. | |
| dc.contributor.author | Coomans, A. | |
| dc.contributor.author | Borgonie, G. | |
| dc.date | 2008 | |
| dc.date.accessioned | 2016-03-15T10:03:03Z | |
| dc.date.available | 2016-03-15T10:03:03Z | |
| dc.identifier.uri | https://orfeo.belnet.be/handle/internal/160 | |
| dc.description | <p>One of the unique features of the model organism <i>Caenorhabditis elegans</i> is its invariant development, where a stereotyped cell lineage generates a fixed number of cells with a fixed cell type. It remains unclear how embryonic development evolved within the nematodes to give rise to the complex, invariant cell lineage of <i>C. elegans</i>. Therefore, we determined the embryonic cell lineage of the nematode, <i>Rhabditophanes</i> sp. (family Alloionematidae) and made detailed cell-by-cell comparison with the known cell lineages of <i>C. elegans, Pellioditis marina </i>and <i>Halicephalobus gingivalis</i>. This gave us a unique data set of four embryonic cell lineages, which allowed a detailed comparison between these cell lineages at the level of each individual cell. This lineage comparison revealed a similar complex polyclonal fate distribution in all four nematode species (85% of the cells have the same fate). It is striking that there is a conservation of a '<i>C. elegans'</i> like polyclonal cell lineage with strong left-right asymmetry. We propose that an early symmetry-breaking event in nematodes of clade IV-V is a major developmental constraint which shapes their asymmetric cell lineage.</p> | |
| dc.language | eng | |
| dc.title | The embryonic cell lineage of the nematode <i>Rhabditophanes </i>sp. | |
| dc.type | Article | |
| dc.subject.frascati | Biological sciences | |
| dc.audience | Scientific | |
| dc.subject.free | Biological collection and data management | |
| dc.source.title | International Journal of Developmental Biology | |
| dc.source.volume | 52 | |
| dc.source.page | 963-967 | |
| Orfeo.peerreviewed | Yes | |
| dc.identifier.rmca | 2195 |
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