We validate formaldehyde (HCHO) vertical column densities (VCDs) from Ozone Mapping and Profiler Suite Nadir Mapper (OMPS-NM) instruments onboard the Suomi National Polar-orbiting Partnership (Suomi NPP) satellite for 2012–2020 and National Oceanic and Atmospheric Administration-20 (NOAA-20) satellite for 2018–2020, hereafter referred to as OMPS-NPP and OMPS-N20, with ground-based Fourier-Transform Infrared (FTIR) observations of the Network for the Detection of Atmospheric Composition Change (NDACC). OMPS-NPP/N20 HCHO products reproduce seasonal variability at 24 FTIR sites. Monthly variability of OMPS-NPP/N20 has a very good agreement with FTIR, showing correlation coefficients of 0.83 and 0.88, respectively. OMPS-NPP (N20) biases averaged over all sites are −0.9 (4) ± 3 (6)\%. However, at clean sites (with VCDs < 4.0 × 1015 molecules cm−2), positive biases of 20 (32) ± 6 (18)\% occur for OMPS-NPP (N20). At sites with HCHO VCDs > 4.0 × 1015 molecules cm−2, negative biases of −15\% ± 4\% appear for OMPS-NPP, but OMPS-N20 shows smaller bias of 0.5\% ± 6\% due to its smaller ground pixel footprints. Therefore, smaller satellite footprint sizes are important in distinguishing small-scale plumes. In addition, we discuss a bias correction and provide lower limit for the monthly uncertainty of OMPS-NPP/N20 HCHO products. The total uncertainty for OMPS-NPP (N20) at clean sites is 0.7 (0.8) × 1015 molecules cm−2, corresponding to a relative uncertainty of 32 (30)\%. In the case of HCHO VCDs > 4.0 × 1015 molecules cm−2, however, the relative uncertainty in HCHO VCDs for OMPS-NPP (N20) decreases to 31 (18)\%.