According to a 2019 United Nations report, of all the known species, up to 1 million face extinction globally. Despite being considered a pressing global risk with several international efforts to protect and to restore, biodiversity loss and the degradation of ecosystems continue at an alarming rate. In December 2022, the UN Biodiversity Conference (COP15) saw the adoption of the Kunming-Montreal Global Biodiversity Framework, where four overarching international goals for biodiversity and 23 targets were set. While this is a positive step towards addressing the drivers of biodiversity loss, we will need not just public and political will but also more effective methods to integrate and use scientific information to reach the goals and targets outlined. To facilitate this, scientists and research institutions need to establish alternative and new approaches to transform the way science is conducted, communicated, and integrated into the policymaking process. This will require the scientific community to become proficient at working in interdisciplinary and transdisciplinary teams, establishing connectivity across scientific disciplines and engaging in the policymaking process to ensure that the best available scientific evidence is not only comprehensible to decision-makers but also timely and relevant. This commentary details how scientists can embrace transformative change within and outside of their own communities to increase the impact of their research and help reach global targets that benefit society.