The Lower Congo region encompasses the South Atlantic passive margin of the Democratic Republic of Congo (Central Africa). It is host to the lowermost course of the Congo River, cutting through the Central African Atlantic Swell (CAAS). The region is underlain by litho-structural units of the Pan-African West Congo Belt, which consists of different tectono-metamorphic domains. The Precambrian basement is covered to the west by marine deposits of the South Atlantic Ocean and to the east by continental deposits of the Congo Basin. In this study we aim to constrain the timing of uplift and exhumation of the CAAS by using apatite fission track (AFT) thermochronology in combination with an updated overview of the geology and geomorphology of the Lower Congo region. AFT ages vary widely between 108 and 312 Ma. Short track lengths (11 12 μm) and broad, complex track length dis tributions indicate mixed ages between multiple thermal events. We derive the timing of exhumation from in verse thermal history models, that show that the Lower Congo region experienced a first exhumation event before Gondwana breakup during the Carboniferous to Middle Jurassic. This event is probably related to com pressive forces at the boundaries of Gondwana. Both rifting and subsequent opening of the South Atlantic Ocean do not seem to have had a pronounced effect on the CAAS region. During the Late Cretaceous to Palaeogene, a slight reheating is suggested and could be due to subsidence and consequential modest reburial of the Lower Congo rocks. A second phase of exhumation initiated around the Palaeogene Neogene and eventually emplaced the sampled rocks at surface temperatures. The multi-phased differential denudation results from reactivation of fault-bounded tectono-metamorphic blocks of the Precambrian basement, controlled by the combination of two systems of faults related to the Cretaceous South Atlantic Ocean opening and Pan-African orogeny respectively. Dif ferential denudation of the Lower Congo region is also well-marked by independent qualitative indicators of the present-day geomorphology including distinct knickpoints and steep valleys along the course of the Lower Congo River, reworking of erosion surfaces and associated laterite crust and contrasting karst morphology