Groundwater salinization and pollution are widespread phenomena that degrade water quality and endanger future water exploitation. The problem is intensifed in aquifers where human activities result in accelerating water quality deterioration, particularly in arid regions. The elevated salinity can also originate from other natural or anthropogenic processes. In the El Berka region Moulares-Redayef mining basin, water quantity and quality are signifcant concerns. This study was undertaken to identify, detect, and delineate the sources and extent of salinization of the Pliocene Quaternary groundwater in El Berka region, using a multi-disciplinary study integrating hydro-geochemical approaches. The aquifer is mainly characterized by high salinity waters (2 to 13 g/L) compared to the surrounding aquifers. The salinity of the groundwater is also impacted by the dissolution of evaporate minerals (anhydrite, gypsum, and halite) in the aquifer. The geophysical approach made it possible to determine the extent of salinity in two particular areas. The frst one, located near the mountainous areas and the Tabeditt wadi (valley), is characterized by relatively high resistance, which confrms its low salinity. The second area, in the center of the plain, is dominated by very low resistivity showing the presence of saline water. This study is intended to guide for decision-makers and planners in the water sector in managing groundwater quality.