Wildlife conflicts between people and large herbivores or mammalian carnivores are widely researched in Africa, but there is limited work on human-crocodile conflicts (HCC). In Uganda, conservation efforts have enabled the recovery of the Nile Crocodile (Crocodylus niloticus) population, yet the expanding human population and activities increasingly overlap with crocodile habitats resulting in negative interactions. This study used a combination of literature review, surveys, and the Nominal Group Technique to investigate the factors underpinning HCC around Murchison Falls Conservation Area. Results indicate that 115 attacks on humans occurred during 2012 2017, 84.3% of these being fatal. Also, 93.1% of the attacks occurred as victims were either fishing or collecting water. Construction of crocodile exclusion enclosures and translocation of problem crocodiles to protected areas were the most preferred mitigation measure. To reduce the prevalence of human injuries and offset local hostility toward crocodiles, conservation actors need to actively engage the affected communities.