Landslides are hillslope processes controlled by natural changing topographic conditions. Landslides are also influenced by human activities. Yet, understanding the space-time occurrence of landslides and their interactions with these typically long-term natural and short-term human-induced controls remains a key challenge in many regions, especially in tropical environments where data scarcity is commonplace. Here we decipher these dynamic processes in the Ruzizi Gorge located in the Kivu Rift (Central Africa), that is an exceptional geomorphological landmark whose origin is associated with the rerouting of >7000 km2 of drainage area from Lake Kivu during the Holocene. This bedrock river has also seen its landscape disturbed over the past decades by the development of the city of Bukavu (DR Congo). In this study, we combine detailed field observations, historical aerial photographs, archive analysis and satellite imagery to compile a multi-temporal inventory of 385 landslides and constrain their dynamics. We show that extremely high incision rates during the early stage of the formation of the gorge explain the space-time clustering of thousand-year-old large (up to ∼2 km2) landslides, independently from the lithological context. These landslides are currently non-active and poorly eroded. Their deposit areas partly cover the riverbed with boulders, armouring the channel and inhibiting further incision. The landslides that occurred over the last 60 years are shallower slope failures of smaller size and higher mobility. They tend to disappear rather quickly from the landscape, sometimes within a few years. Their distribution is primarily controlled by threshold slopes, lithology, and the past large landslides, the influence of the land use being less pronounced. Overall, the sediment mobilization rates associated with these high frequency landslides significantly outpace the extreme landslide erosion pulse associated with the gorge formation. Our results provide insight on interactions between channel-hillslope coupling and feedbacks among landslide processes and river gorge formation in a unique environment.