The Orbiting Carbon Observatory 2 (OCO-2) is NASA's first Earth observation satellite mission dedicated to studying the sources and sinks of carbon dioxide (CO2) on a global scale. The observations of reflected sunlight are inverted in a retrieval algorithm to produce estimates of the dry air mole-fractions of CO2 (XCO2). The OCO-2 Level 2 data release, version 11.1 (v11.1) retrievals from the Atmospheric Carbon Observations from Space (ACOS) algorithm, includes significant improvements in the XCO2 data product compared to older OCO-2 data versions. This work compares the v11.1 XCO2 from OCO-2 against XCO2 estimates collected from a global ground-based network known as the Total Carbon Column Observing Network (TCCON), OCO-2's primary validation source. The OCO-2 project provides a version of the Level 2 data product, called “lite” files that include calibrated and bias-corrected XCO2 values, accessible together with all OCO-2 data products through the NASA Goddard Earth Sciences Data and Information Services Center (GES DISC). This work shows that OCO-2 XCO2 observations made between September 2014 and December 2023, after quality filtering and the application of an averaging kernel correction, agree well with coincident TCCON data for all OCO-2 observational modes of land (nadir, glint, target) and ocean (glint). The aggregated, bias-corrected, and quality-filtered absolute average bias values are less than or equal to 0.20 parts per million (ppm) globally for all OCO-2 observation modes, where the biases do not indicate a statistically significant time dependence. The land nadir/glint mode has the lowest bias value of −0.03 ± 0.85 ppm.