Ozone is produced from the photodissociation of molecular oxygen by ultraviolet radiation (lambda less than 242.4 nm). It is destroyed by direct recombination with oxygen atoms. This recombination can be catalyzed by hydroxyl radicals, nitrogen and chlorine oxides. In other words, the ozone layer can be altered by species produced either by natural processes in the biosphere or by human activity in relation with agriculture or industry. As an example, man-made chlorofluorocarbons should reduce the ozone amount by a few percent if the present release into the atmosphere continues. On the other hand, an increase of carbon dioxide should cool the upper stratosphere and consequently increase the ozone concentration, This chapter presents results from an interactive chemical/radiative/dynamic one-dimensional model with several coupled perturbation scenarios.