Robust calibration and validation (Cal and Val) should guarantee the accuracy of the retrieved information, make the remote sensing data consistent and traceable, and maintain the sensor performance during the operational phase. The DRAGON program has set up many remote sensing research topics on various application domains. In order to promote the effectiveness of data modeling and interpretation, it is necessary to solve various challenges in Cal and Val for quantitative RS applications. This project in the DRAGON 4 program aims to promote the cooperation of the Cal and Val experts from European and Chinese institutes in Cal and Val activities, and several achievements have been obtained in the advanced on-orbit optical sensor calibration, as well as microwave remote sensor calibration and product generation. The outcomes of the project have benefited the related remote sensing modeling and product retrieval, and promoted the radiometric calibration network (RadCalNet) as an international operational network for calibration, intercalibration, and validation. Moreover, this project provided local governments with a more accurate OMI NO2 data in China, which were used to study the air quality control during APEC period, Parade period and G20 period. This will be of ongoing be value for monitoring atmospheric environmental quality and formulating pollution control strategies.