The reactions of CF3O-, CF3O-·H2O and CF3O-·HF with HCl and of CF3O- with H2O have been studied at room temperature in a flowing afterglow instrument. All reactions with HCl proceed at the gas kinetic rate. The reaction of CF3O- with HCl proceeds by fluoride transfer, whereas CF3O-·H2O and CF3O-·HF react with HCl by ligand switching. The Gibbs free energy change of the reaction of CF3O- with H2O has been determined at room temperature as well as the collisional dissociation rate constant of CF3O-·H2O ions.