ULISSE (USOCs KnowLedge Integration and dissemination for Space Science and Exploration) is an FP7 European Commission project proposed by the USOC (User Support and Operation Centre) network in charge of the European operations on the International Space Station. The partners are led by TELESPAZIO in Italy and include as well knowledge management experts as data providers in all the related disciplines, life sciences have an important weight through the in involvement of the MEDES consortium, a space medicine group organised by CNES and research hospitals in Toulouse.