The impact of domain size on regional climate simulations is explored in the context of a state-of-the-art regional model centered over western Europe. It is found that the quality of the climate simulations is highly dependent on the domain size. Moreover, the choice of an optimal version is more complex than usually thought, the less appropriate domain having an intermediate size (about 3000 km × 3000 km), and the best versions nearly cover a quarter of the Northern Hemisphere. The use of periodically reinitialized trajectories does improve the climate of suboptimal models but leads to unrealistic dynamical behaviors. The implications for regional climate simulations are briefly discussed.